circRNA basic information
circBase ID: hsa_circ_0059655
Name: hsa_circ_PYGB
Synonym: -
Host Gene: PYGB
Genomic location(hg19): chr20:25276239-25278648:+
Genomic location(hg38): chr20:25295603-25298012:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0003175
MONDO name: salivary gland adenoid cystic carcinoma
Disease details: salivary adenoid cystic carcinoma / SACC
Disease DO ID:
 4866
Disease MeSH ID:
 -
Disease NCIt ID:
 C8026
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

SACC tissues; paired normal submandibular gland(SMG) tissues
Cell lines:

SACC-83
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: CCND1, SOX4, MTHFD1L, ZNF257, KLHL42, ZNF286A, DAPK1, DBN1
Associated microRNA: hsa-miR-338-3p, miR-338-3p
Biological function: hsa_circ_0059655 promotes proliferation, migration, and invasion of SACC-83 cells; knockdown of hsa_circ_0059655 decreases these malignant phenotypes.
Molecular mechanism: hsa_circ_0059655 functions as a sponge of miR-338-3p and may regulate SACC occurrence and development through the hsa_circ_0059655 / miR-338-3p / CCND1 ceRNA axis.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
M
Validation methods:

Microarray; Clinical Sample Validation; Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; Western Blot; Wound Healing Assay; Transwell Assay
Clinical significance:

-
Description:

This study identified hsa_circ_0059655 as a PYGB-derived circRNA involved in SACC. It may act as a miR-338-3p sponge and regulate CCND1-related ceRNA signaling, thereby promoting proliferation, migration, and invasion of SACC-83 cells. Its disease-expression evidence is based on microarray profiling rather than RT-qPCR validation in clinical samples.
Confidence score:

0.6093
Other information
Title:

Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)
Published: 2018
PubMed ID: 30672444
Study type:

combined biological and clinical study
Data availability: Supplementary materials
Code availability: -