| Expression pattern: |
UP |
| Associated gene: |
AMPK, p-AMPK, mTOR, p-mTOR |
| Associated microRNA: |
- |
| Biological function: |
Promotes PTC cell proliferation and invasion; knockdown suppresses proliferation and invasion in vitro. |
| Molecular mechanism: |
has_circ_0008274 acts as a tumor promoter in PTC by modulating the AMPK/mTOR signaling pathway. |
| Biological pathway or process: |
AMPK (other); proliferation (promotes); invasion (promotes); apoptosis (inhibits); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High circ_0008274 expression was significantly associated with TNM stage and lymph node metastasis; it may serve as a potential therapeutic candidate in PTC treatment. |
| Description: |
This study reports that has_circ_0008274 is up-regulated in papillary thyroid carcinoma tissues and cell lines. Functional knockdown experiments indicate that has_circ_0008274 promotes PTC cell proliferation and invasion, and the proposed mechanism involves modulation of the AMPK/mTOR signaling pathway. Its expression is associated with TNM stage and lymph node metastasis, suggesting potential clinical relevance as a therapeutic target. |
| Confidence score: |
0.6093 |