| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-620 |
| Biological function: |
Overexpression of circSMARCA5 inhibited cervical cancer cell proliferation, migration and invasion, and induced cell cycle arrest. |
| Molecular mechanism: |
circSMARCA5 acts as a miR-620 sponge, binds to miR-620, downregulates miR-620 expression, and modulates cervical cancer proliferation and invasion through miR-620. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis |
| Clinical significance: |
circSMARCA5 may be a potential biomarker and therapeutic target for cervical cancer; its expression was related to CC I-IV stages. |
| Description: |
circSMARCA5/hsa_circ_0001445 is downregulated in cervical cancer tissues and cells. Functionally, circSMARCA5 suppresses cervical cancer cell proliferation, migration and invasion and induces cell cycle arrest. Mechanistically, circSMARCA5 binds and inhibits miR-620, suggesting a circSMARCA5/miR-620 regulatory axis with potential therapeutic relevance. |
| Confidence score: |
0.7177 |