| Expression pattern: |
UP |
| Associated gene: |
MAP3K3, SLC1A5, IGF2, KDM1A |
| Associated microRNA: |
miR-491-5P, miR-137, miR-137-3p |
| Biological function: |
Potential oncogenic role in CRC (discussed), and is up-regulated in CRC patient blood. |
| Molecular mechanism: |
Discussed ceRNA mechanism: circ-LDLRAD3 may sponge miR-491-5P and miR-137/miR-137-3P to regulate targets such as MAP3K3, IGF2, SLC1A5 and potentially affect CRC progression. |
| Biological pathway or process: |
ceRNA regulation (other); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
circ-LDLRAD3 could be used as a diagnostic marker for CRC (AUC 76.8%, sensitivity 64%, specificity 95%). |
| Description: |
circ-LDLRAD3 is significantly up-regulated in CRC patient blood compared with healthy controls and shows diagnostic value. The discussion suggests circ-LDLRAD3 may regulate CRC progression through ceRNA interactions with miR-491-5P and miR-137 family members, affecting targets such as MAP3K3, IGF2 and SLC1A5. |
| Confidence score: |
0.4187 |