circRNA basic information
circBase ID: hsa_circ_0009910
Name: -
Synonym: circ_0009910
Host Gene: -
Genomic location(hg19): chr1:12049221-12052747:+
Genomic location(hg38): chr1:11989164-11992690:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; matched normal gastric tissues; adjacent non-tumor tissues
Cell lines:

BGC823; SGC7901; AGS; MGC803; MKN45; GES1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes GC cell proliferation, colony formation, migration, invasion, metastasis-related behavior, and EMT; knockdown suppresses these malignant phenotypes.
Molecular mechanism: circ_0009910 promotes gastric cancer progression by inducing EMT, with knockdown increasing E-cadherin and decreasing N-cadherin and Snail.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

circ_0009910 expression is associated with clinical stage, distant metastasis, differentiation, worse overall survival, and is an independent prognostic indicator for gastric cancer.
Description:

circ_0009910 is up-regulated in gastric cancer tissues and cell lines and is associated with advanced clinicopathological features and poor overall survival. Functionally, circ_0009910 promotes proliferation, colony formation, migration, invasion, and EMT of gastric cancer cells, suggesting its value as a prognostic biomarker and potential therapeutic target.
Confidence score:

0.6568
Other information
Title:

Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 30556864
Study type:

combined biological and clinical study
Data availability: -
Code availability: -