circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: Circular RNA Itchy E3 ubiquitin protein ligase / Circ-ITCH
Host Gene: Itchy E3 ubiquitin protein ligase
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005140
MONDO name: ovarian carcinoma
Disease details: epithelial ovarian cancer / EOC
Disease DO ID:
 4001
Disease MeSH ID:
 -
Disease NCIt ID:
 C4908
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovary
Cell lines:

SKOV3; A-2780; OVCAR-3; HO-8910; IOSE80
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-10a
Biological function: suppresses proliferation and promotes apoptosis in SKOV3 epithelial ovarian cancer cells
Molecular mechanism: Circ-ITCH suppresses proliferation and promotes apoptosis by targeting and sponging miR-10a
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Bioinformatics Analysis
Clinical significance:

providing a potential therapeutic target for EOC
Description:

Circ-ITCH is down-regulated in human epithelial ovarian cancer cell lines compared with normal ovarian epithelial cells. In SKOV3 cells, Circ-ITCH suppresses proliferation and promotes apoptosis, mainly through targeting/sponging miR-10a, suggesting a potential therapeutic relevance in EOC.
Confidence score:

0.4376
Other information
Title:

Circular RNA ITCH suppresses proliferation and promotes apoptosis in human epithelial ovarian cancer cells by sponging miR-10a-alpha.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 30556849
Study type:

biological research
Data availability: Tissue-Specific CircRNA Database (TSCD) on gb.whu.edu.cn/TSCD/; chr20:34424479|34457474
Code availability: -