| Expression pattern: |
UP |
| Associated gene: |
JMJD2C |
| Associated microRNA: |
miR-335-5p / miR-335 |
| Biological function: |
circZMYM2 promoted pancreatic cancer cell proliferation and invasion, inhibited apoptosis, and promoted tumorigenesis in vivo. |
| Molecular mechanism: |
circZMYM2 functions as a miR-335-5p sponge and regulates the downstream oncogene JMJD2C. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circZMYM2 is up-regulated in pancreatic cancer tissues and cell lines. It promotes PC cell proliferation, invasion and in vivo tumor growth while inhibiting apoptosis, acting through a circZMYM2/miR-335-5p/JMJD2C ceRNA axis. |
| Confidence score: |
0.7795 |