| Expression pattern: |
UP |
| Associated gene: |
SULT2B1 |
| Associated microRNA: |
miR-140-5p |
| Biological function: |
circDYNC1H1 promotes HCC cell proliferation, migration, tumor growth and progression; silencing circDYNC1H1 restrains proliferation and migration and delays tumor growth. |
| Molecular mechanism: |
circDYNC1H1 acts as a ceRNA/sponge for miR-140-5p, thereby upregulating SULT2B1 expression through the miR-140-5p/SULT2B1 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Upregulation of circDYNC1H1 in HCC tissues and cell lines indicates its potential as a biomarker for HCC and as an effective target for HCC treatment. |
| Description: |
circDYNC1H1 is upregulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration and tumor growth by sponging miR-140-5p and increasing SULT2B1 expression, suggesting potential biomarker and therapeutic-target value. |
| Confidence score: |
0.7032 |