circRNA basic information
circBase ID: hsa_circ_0092509
Name: hsa_circ_NT5C2
Synonym: circ-NT5C2
Host Gene: NT5C2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissues; matched adjacent normal bone
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with clinical stage and distant metastasis; acts as a potential poor prognostic biomarker in osteosarcoma.
Molecular mechanism: -
Biological pathway or process:

metastasis (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

High circ-NT5C2 expression was correlated with clinical stage and distant metastasis, shorter OS and DFS, and may serve as an independent prognostic biomarker for poor prognosis.
Description:

This clinical study found that circ-NT5C2/hsa_circ_0092509 is significantly up-regulated in osteosarcoma tissues compared with adjacent normal bone tissues. Higher circ-NT5C2 expression is associated with advanced clinical stage, distant metastasis, shorter OS and DFS, and independent prediction of poor prognosis. The study did not experimentally define a molecular mechanism for circ-NT5C2 in osteosarcoma.
Confidence score:

0.4758
Other information
Title:

Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 30338784
Study type:

clinical study
Data availability: -
Code availability: -