| Expression pattern: |
DN |
| Associated gene: |
p38 MAPK, PI3K, AKT, Bcl-2, Bax |
| Associated microRNA: |
- |
| Biological function: |
Functions as a tumor suppressor in OSCC; overexpression suppresses TSCC1 cell proliferation, induces G0/G1 cell cycle arrest, and promotes apoptosis. |
| Molecular mechanism: |
circRNA_102459 overexpression suppresses MAPK and PI3K/Akt signaling, reduces anti-apoptotic Bcl-2 expression, and increases pro-apoptotic Bax expression. |
| Biological pathway or process: |
MAPK (inhibits); PI3K/AKT (inhibits); proliferation (inhibits); cell cycle (inhibits); apoptosis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
Expression was significantly associated with clinical stage, tumor differentiation, and lymph node metastasis; may be a valuable diagnostic biomarker of OSCC. |
| Description: |
hsa_circRNA_102459 is down-regulated in OSCC and is proposed to act as a tumor-suppressive circRNA. Its overexpression inhibits TSCC1 cell proliferation, arrests the cell cycle at G0/G1, promotes apoptosis, and suppresses MAPK and PI3K/Akt signaling; its expression is also associated with clinical stage, tumor differentiation, and lymph node metastasis. |
| Confidence score: |
0.7295 |