circRNA basic information
circBase ID: hsa_circ_0005320
Name: hsa_circ_SEPT9
Synonym: hsacirc_0005320
Host Gene: SEPT9
Genomic location(hg19): chr17:75398140-75398785:+
Genomic location(hg38): chr17:77402058-77402703:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000544
MONDO name: mucosal melanoma
Disease details: oral mucosal melanoma / OMM
Disease DO ID:
 0050929
Disease MeSH ID:
 -
Disease NCIt ID:
 C114828
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor; metastatic lymph nodes; paired adjacent normal tissues; non-metastatic nodes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Sept-9, GNG7
Associated microRNA: -
Biological function: Associated with metastatic OMM; may contribute to OMM tumorigenesis and metastasis as a ceRNA; associated with GTPase activity.
Molecular mechanism: Bioinformatics-predicted ceRNA mechanism involving circRNA-miRNA interactions and potential mRNA targets; associated with host gene SEPT9-related functions.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other); cell cycle (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; ROC Analysis
Clinical significance:

Potential diagnostic biomarker for OMM; ROC AUC value was 0.833.
Description:

hsa_circ_0005320 is significantly upregulated in OMM primary tumors and metastatic lymph nodes. The study predicts that it may function as a ceRNA in OMM progression and metastasis, with potential diagnostic value.
Confidence score:

0.5047
Other information
Title:

Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.

Journal: American journal of cancer research
Published: 2018
PubMed ID: 30323971
Study type:

combined clinical and bioinformatics study
Data availability: Table S1; Table S2; Table S3
Code availability: -