circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: -
Host Gene: ZNF609
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples; adjacent non-tumor tissues; cancerous tissues
Cell lines:

BEAS-2B; A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Overexpressing hsa_circ-ZNF609 inhibited A549 cell proliferation and promoted apoptosis; the authors suggested a tumor suppressive role in lung adenocarcinoma.
Molecular mechanism: Not mechanistically defined; functional assays showed effects on proliferation and apoptosis.
Biological pathway or process:

proliferation (inhibits); apoptosis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; ROC Analysis; Survival Analysis
Clinical significance:

High expression was positively correlated with TNM stage, lymph node metastasis, smoking, diagnostic AUC, and shorter overall survival and disease-free rates.
Description:

hsa_circ-ZNF609 was up-regulated in lung adenocarcinoma serum and tissues and had diagnostic and prognostic relevance. Overexpression inhibited A549 proliferation and promoted apoptosis, suggesting a tumor-suppressive functional effect in vitro despite high expression being associated with poorer survival in the Results section.
Confidence score:

0.6155
Other information
Title:

Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.

Journal: Clinical laboratory
Published: 2021
PubMed ID: 34383411
Study type:

combined biological and clinical study
Data availability: -
Code availability: -