| Expression pattern: |
DN |
| Associated gene: |
APC2, AGO2 |
| Associated microRNA: |
miR-582 |
| Biological function: |
Acts as a tumor suppressor in colorectal cancer; inhibits CRC cell proliferation, EMT, migration, invasion, tumor growth and metastasis. |
| Molecular mechanism: |
hsa_circ_0009361 functions as a ceRNA sponge for miR-582, upregulates APC2 expression, and inhibits Wnt/beta-catenin signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining |
| Clinical significance: |
The hsa_circ_0009361/miR-582/APC2 network may represent a potential therapeutic target for CRC patients. |
| Description: |
hsa_circ_0009361 is downregulated in colorectal cancer tissues and cells and functions as a tumor suppressor. It sponges miR-582 to upregulate APC2, thereby inhibiting Wnt/beta-catenin signaling and suppressing CRC cell proliferation, EMT, migration, invasion, tumor growth and metastasis. The hsa_circ_0009361/miR-582/APC2 axis is proposed as a potential therapeutic target for CRC. |
| Confidence score: |
0.8511 |