| Expression pattern: |
DN |
| Associated gene: |
CCL5, INSC, SLC9A1, SLC34A1 |
| Associated microRNA: |
hsa-miR-614, hsa-miR-645, hsa-miR-4689 |
| Biological function: |
Potential tumor-suppressive circRNA reduced in CRC spheroid models and liver metastatic tissues; predicted to regulate oncogenic miRNAs and downstream tumor-suppressive genes in a CRC progression network. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network/ceRNA mechanism involving hsa-miR-614, hsa-miR-645, hsa-miR-4689 and downstream tumor-suppressive genes associated with favorable survival and cancer stemness. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (promotes); proliferation (inhibits); stemness (inhibits); JAK/STAT (other); cell cycle (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNase R Treatment; circRNA-seq; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis |
| Clinical significance: |
Potential diagnostic biomarker and therapeutic target in colorectal cancer based on consistent downregulation in CRC spheroids and liver metastatic tissues. |
| Description: |
hsa_circ_0067353 was identified as a potential tumor-suppressive circRNA downregulated in CRC spheroid models and liver metastatic tissues. The study places it in a predicted circRNA-miRNA-mRNA network involving oncogenic miRNAs and tumor-suppressive genes associated with cancer stemness, differentiation, apoptosis-related processes, and CRC progression. |
| Confidence score: |
0.5746 |