| Expression pattern: |
UP |
| Associated gene: |
RAC2 mRNA, NOP2/Sun RNA methyltransferase 5 / NSUN5 |
| Associated microRNA: |
miR-571 |
| Biological function: |
circ_0102913 promotes proliferation, colony formation, migration, invasion, and in vivo tumorigenesis of CRC cells. |
| Molecular mechanism: |
m5C modification increases circ_0102913 stability and expression; circ_0102913 acts as a ceRNA by sequestering miR-571, thereby restoring RAC2 mRNA expression and promoting malignant progression of CRC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); m5A modification (other); mRNA stability (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; RNA Pull-Down; Luciferase Reporter Assay; Colony Formation Assay; EdU Staining; Transwell Assay; In Vivo Animal Model; Western Blot; RIP (RNA Immunoprecipitation); Actinomycin D / DRB Stability Assay |
| Clinical significance: |
circ_0102913 was significantly highly expressed in clinical CRC tissues, and the authors suggest inhibiting circ_0102913 as a potential therapeutic avenue. |
| Description: |
circ_0102913 is a human ATXN3-derived circRNA that is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-571 and restoring RAC2 expression. Its elevated expression is attributed at least partly to NSUN5-associated m5C modification, which increases circ_0102913 stability. |
| Confidence score: |
0.8275 |