HCC tissues; nontumor tissue samples; corresponding nontumourous tissues
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not specified
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
hsa_circ_0000267 was among the top up-regulated circRNAs identified by high-throughput circRNA sequencing and was validated by RT-qPCR as significantly increased in HCC tissues compared with corresponding nontumourous tissues. No functional or mechanistic experiments were reported for this circRNA.
0.5841
Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.
combined biological and clinical study