| Expression pattern: |
UP |
| Associated gene: |
SOX8, caspase-3 |
| Associated microRNA: |
miR-124 |
| Biological function: |
CircHIPK3 inhibits apoptosis of OA chondrocytes; knockdown of CircHIPK3 promotes OA chondrocyte apoptosis and increases caspase-3 expression. |
| Molecular mechanism: |
CircHIPK3 acts as a sponge of miR-124 to regulate SOX8 expression in OA chondrocytes. |
| Biological pathway or process: |
apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
The molecular mechanism of CircHIPK3 in present study is expected to provide new ideas for the treatment of osteoarthritis. |
| Description: |
CircHIPK3 is significantly up-regulated in human osteoarthritis cartilage tissue and OA chondrocytes. It functions through a CircHIPK3/miR-124/SOX8 regulatory axis, where CircHIPK3 sponges miR-124 to regulate SOX8 and thereby inhibits OA chondrocyte apoptosis; knockdown of CircHIPK3 increases miR-124 activity, suppresses SOX8, and promotes apoptosis. |
| Confidence score: |
0.6099 |