circRNA basic information
circBase ID: -
Name: hsa_circ_CDK6
Synonym: hsa_circ_000984
Host Gene: CDK6
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; corresponding non-tumor tissues; matched normal lung tissues
Cell lines:

H1975; SPC-A1; H1299; HCC827; PC 9; A549; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: beta-catenin, cyclin D1, c-myc, N-cadherin, vimentin, caspase 3, caspase 9
Associated microRNA: -
Biological function: Promotes NSCLC cell proliferation, colony formation, migration, invasion, metastasis, and EMT; inhibits apoptosis; associated with advanced TNM stage, lymph node metastasis, and poor prognosis.
Molecular mechanism: hsa_circ_000984 exerts oncogenic roles in NSCLC by activating or modulating the Wnt/beta-catenin signaling pathway, with effects on beta-catenin, cyclin D1, c-myc, and EMT-associated proteins.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

High hsa_circ_000984 expression is associated with advanced TNM stage, lymph node metastasis, shorter overall survival and disease-free survival, and may serve as an independent poor prognostic indicator and potential prognostic biomarker in NSCLC.
Description:

hsa_circ_000984 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration, invasion, EMT and Wnt/beta-catenin signaling while increasing apoptosis, and high expression predicts poor survival in NSCLC patients.
Confidence score:

0.6589
Other information
Title:

Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/beta-catenin pathway.

Journal: European review for medical and pharmacological sciences
Published: 2019
PubMed ID: 31081091
Study type:

combined biological and clinical study
Data availability: -
Code availability: -