| Expression pattern: |
UP |
| Associated gene: |
PPM1F |
| Associated microRNA: |
miR-455-3p |
| Biological function: |
Promotes xenograft tumor growth and HCC cell proliferation, metastasis, invasion, EMT, cell cycle progression, and inhibits apoptosis. |
| Molecular mechanism: |
circSEC24A functions as a ceRNA/miRNA sponge for miR-455-3p, thereby increasing PPM1F expression and promoting malignant behaviors of HCC cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSEC24A expression is associated with shorter survival time in HCC patients and may be a potential biomarker or therapeutic target. |
| Description: |
circSEC24A is up-regulated in HCC tissues and cells, and high expression is associated with shorter patient survival. Functionally, circSEC24A promotes HCC tumor growth, proliferation, metastasis, invasion and EMT while suppressing apoptosis, mainly by sponging miR-455-3p to increase PPM1F expression. |
| Confidence score: |
0.8354 |