| Expression pattern: |
UP |
| Associated gene: |
PD-L1 mRNA, PD-L1, sPD-L1 |
| Associated microRNA: |
miR-320a |
| Biological function: |
circ_0001006 promotes NSCLC cell proliferation, migration, invasion, and immune escape; circ_0001006 knockdown activates CD8+ T cells and enhances immune-related cytokine secretion. |
| Molecular mechanism: |
circ_0001006 acts as a sponge for miR-320a and regulates PD-L1 expression and secretion, thereby modulating CD8+ T cell activation and NSCLC immune escape. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; ELISA; Luciferase Reporter Assay; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High circ_0001006 expression was associated with differentiation, high TNM stage, positive lymph node metastasis, and shorter overall survival; circ_0001006 may serve as a prognostic biomarker and therapeutic target for NSCLC. |
| Description: |
circ_0001006 is up-regulated in NSCLC tissues and cell lines and high expression predicts poorer overall survival. Functionally, circ_0001006 promotes NSCLC proliferation, migration, invasion, and immune escape by sponging miR-320a and regulating PD-L1 expression/secretion, thereby suppressing CD8+ T cell activity. |
| Confidence score: |
0.7365 |