circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: hsa_circRNA_103829
Host Gene: HMGCS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005097
MONDO name: squamous cell lung carcinoma
Disease details: lung squamous cell carcinoma / LSCC
Disease DO ID:
 3907
Disease MeSH ID:
 -
Disease NCIt ID:
 C3493
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LSCC tissues; adjacent normal tissues; tumor tissue; non-tumor lung tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGCS1
Associated microRNA: hsa-miR-625-3p, hsa-miR-129-5p, hsa-miR-532-5p, hsa-miR-548c-3p, hsa-let-7c-5p
Biological function: May play important roles in LSCC carcinogenesis.
Molecular mechanism: Predicted miRNA-circRNA interaction through putative miRNA response elements.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_103829 was identified as an up-regulated key circRNA in LSCC and validated by qRT-PCR. It was predicted to interact with multiple miRNAs, suggesting a possible miRNA-sponge role in LSCC carcinogenesis.
Confidence score:

0.5135
Other information
Title:

Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.

Journal: American journal of translational research
Published: 2018
PubMed ID: 29636867
Study type:

combined biological and clinical study
Data availability: -
Code availability: -