| Expression pattern: |
UP |
| Associated gene: |
SOX2 |
| Associated microRNA: |
miR-490-5p |
| Biological function: |
promotes HCC cell proliferation and migration; inhibits apoptosis; facilitates HCC malignant progression |
| Molecular mechanism: |
hsa_circ_0103809 acts as an endogenous sponge or decoy for miR-490-5p, leading to derepression of SOX2 expression through the miR-490-5p/SOX2 signaling pathway |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
increased hsa_circ_0103809 expression in HCC tissues was significantly correlated with poor prognosis; may serve as a diagnostic and prognostic biomarker and potential therapeutic target for HCC |
| Description: |
hsa_circ_0103809 is up-regulated in HCC tissues and cell lines and is associated with poor prognosis. Functionally, it promotes HCC cell proliferation and migration and suppresses apoptosis. Mechanistically, it acts as a miR-490-5p sponge to derepress SOX2 expression, forming a hsa_circ_0103809/miR-490-5p/SOX2 regulatory axis. |
| Confidence score: |
0.8413 |