| Expression pattern: |
DN |
| Associated gene: |
NTRK3 |
| Associated microRNA: |
miR-485-3p |
| Biological function: |
hsa_circ_0009172 acts as a tumor suppressor in gastric cancer; overexpression inhibits gastric cancer cell proliferation, viability, clone formation, migration, invasion, EMT-related protein changes, and xenograft tumor growth. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0009172 sponges miR-485-3p and regulates the miR-485-3p target NTRK3, thereby attenuating gastric cancer progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circRNA_0009172 expression correlates with poor prognosis, TNM stage, and histological grade in gastric cancer patients; high expression is associated with higher survival rate. |
| Description: |
hsa_circ_0009172 is downregulated in gastric cancer tissues and cell lines, and low expression is associated with poorer patient survival. Functionally, restoring hsa_circ_0009172 suppresses gastric cancer cell proliferation, migration, invasion, EMT, and xenograft growth. Mechanistically, it acts through a hsa_circ_0009172/miR-485-3p/NTRK3 regulatory axis. |
| Confidence score: |
0.8066 |