| Expression pattern: |
UP |
| Associated gene: |
VDAC1 |
| Associated microRNA: |
miR-577 |
| Biological function: |
Circ_0001326 promotes PCa cell proliferation, colony formation, migration, invasion and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
Circ_0001326 functions as a miR-577 sponge to regulate VDAC1 expression and thereby modulate PCa cell functional behaviors. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ_0001326 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0001326 sponges miR-577 to relieve repression of VDAC1, forming a circ_0001326/miR-577/VDAC1 regulatory cascade. |
| Confidence score: |
0.8175 |