| Expression pattern: |
UP |
| Associated gene: |
Snail-2, AGO2 |
| Associated microRNA: |
miR-506 |
| Biological function: |
promotes cervical cancer cell proliferation and invasion; inhibits G0/G1 phase cell cycle arrest |
| Molecular mechanism: |
circRNA-000284 acts as a miRNA sponge for miR-506 and releases Snail-2 activity/expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); circRIP; Luciferase Reporter Assay; Transfection; CCK8; IF (Immunofluorescence); Cell Cycle Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
may serve as a promising therapeutic target, new diagnostic factor and prognostic marker in cervical cancer |
| Description: |
circRNA-000284 is up-regulated in cervical cancer cell lines and promotes proliferation and invasion. Mechanistically, it functions as a miR-506 sponge, thereby positively regulating Snail-2 and contributing to cervical cancer progression. The study suggests circRNA-000284 may be a therapeutic target and potential diagnostic/prognostic marker. |
| Confidence score: |
0.7006 |