circRNA basic information
circBase ID: hsa_circ_0007534
Name: hsa_circ_DDX42
Synonym: -
Host Gene: DDX42
Genomic location(hg19): chr17:61869771-61877977:+
Genomic location(hg38): chr17:63792411-63800617:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissues; matched adjacent non-tumorous tissues
Cell lines:

FHC; SW620; HCT116; LoVo; SW480; HT29
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Silencing of hsa_circ_0007534 suppresses CRC cell proliferation and induces apoptosis; hsa_circ_0007534 is implicated in CRC initiation and progression.
Molecular mechanism: Silencing hsa_circ_0007534 induces apoptosis with increased caspase-3 activity and decreased Bcl-2/Bax ratio in CRC cells.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

hsa_circ_0007534 expression was correlated with tumor stage and lymph node metastasis and may be a biomarker or therapeutic target of CRC.
Description:

hsa_circ_0007534 is up-regulated in colorectal cancer tissues and CRC cell lines. Its knockdown suppresses proliferation and induces apoptosis in SW620 and LoVo cells, accompanied by increased caspase-3 activity and reduced Bcl-2/Bax ratio. Clinically, higher hsa_circ_0007534 expression is associated with advanced tumor stage and lymph node metastasis, suggesting potential biomarker and therapeutic relevance.
Confidence score:

0.7046
Other information
Title:

Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 29364478
Study type:

combined biological and clinical study
Data availability: -
Code availability: -