| Expression pattern: |
UP |
| Associated gene: |
corresponding target mRNAs |
| Associated microRNA: |
hsa-miR-146b-3p, hsa-miR-23a-5p, hsa-miR-185-3p, hsa-miR-762, hsa-miR-637 |
| Biological function: |
hsa_circRNA_102958 is up-regulated in gastric cancer tissues and cell lines, is associated with TNM stage, and may serve as a potential novel and stable diagnostic biomarker for gastric carcinoma. |
| Molecular mechanism: |
A predicted hsa_circRNA_102958-miRNA-mRNA interaction network suggests a possible ceRNA-related mechanism, but the interactions were predicted rather than experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circRNA_102958 levels were positively associated with TNM stage, and ROC analysis showed an AUC of 0.74 with sensitivity 0.61 and specificity 0.86, suggesting potential diagnostic value in gastric cancer. |
| Description: |
This study identified hsa_circRNA_102958 as an up-regulated circRNA in gastric cancer tissues and cell lines using microarray screening and qRT-PCR validation. Its expression was associated with TNM stage and showed moderate diagnostic performance by ROC analysis. The authors also predicted a hsa_circRNA_102958-miRNA-mRNA network involving five miRNAs, suggesting a possible ceRNA-related regulatory role. |
| Confidence score: |
0.5963 |