circRNA basic information
circBase ID: -
Name: hsa_circ_TNFRSF21
Synonym: hsa-TNFRSF21_0001
Host Gene: TNFRSF21
Genomic location(hg19): chr6:47251674-47254331:.
Genomic location(hg38): chr6:47283938-47286595:.
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0043839
MONDO name: ulcer disease
Disease details: venous ulcers
Disease DO ID:
 -
Disease MeSH ID:
 D014456
Disease NCIt ID:
 C3426
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

healthy skin; acute wounds; wound-edge VU biopsies; wound-edge samples; nonhealing edge of VUs
Cell lines:

primary human epidermal keratinocytes; primary human dermal fibroblasts
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ACTA2, ITGB1, VEGFA, IVL, CCNE1, SALL4, BTLA, KCNK10
Associated microRNA: -
Biological function: Hampers epidermal keratinocyte migration and promotes proliferation; increased expression in VUs may contribute to nonmigratory, hyperproliferative, and abnormally differentiated wound-edge keratinocytes.
Molecular mechanism: Regulates keratinocyte gene networks related to epidermal differentiation, epithelial-to-mesenchymal transition, adhesion, and cell cycle; may regulate VU-related genes through a miRNA sponge mechanism based on circRNA-miRNA-mRNA network analysis.
Biological pathway or process:

proliferation (promotes); migration (inhibits); cell cycle (promotes); EMT (inhibits); ceRNA regulation (other); other pathway/process (inhibits)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Bioinformatics Analysis
Clinical significance:

Upregulated in venous ulcers and may contribute to the pathological nonmigratory, hyperproliferative, and abnormally differentiated state of VU wound-edge keratinocytes.
Description:

hsa-TNFRSF21_0001 is a human circRNA upregulated in venous ulcers. It is mainly cytoplasmic in keratinocytes and promotes proliferation/cell cycle while suppressing migration and differentiation/EMT-related programs, thereby potentially contributing to the abnormal wound-edge keratinocyte phenotype in VU.
Confidence score:

0.7008
Other information
Title:

Circular RNA Signatures of Human Healing and Nonhealing Wounds.

Journal: The Journal of investigative dermatology
Published: 2022
PubMed ID: 35429518
Study type:

combined biological and clinical study
Data availability: GSE174661; GSE188939; www.xulandenlab.com/humanwounds-circrna
Code availability: Supplementary Code S1; Supplementary Code S2