| Expression pattern: |
UP |
| Associated gene: |
SNAIL1, E-cadherin |
| Associated microRNA: |
miR-30c |
| Biological function: |
Promotes bladder cancer cell growth, migration, invasion and metastasis; its silencing induces apoptosis and inhibits tumor growth and metastasis in vivo. |
| Molecular mechanism: |
circPRMT5-related oncogenic regulation via the miR-30c/SNAIL1/E-cadherin axis; circPRMT5 knockdown modulates miR-30c and downstream SNAIL1 and E-cadherin. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes); cell cycle (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry); TUNEL; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
circPRMT5 is highly expressed in bladder cancer tissue and correlates positively with advanced clinical stage and worse survival in patients with bladder cancer. |
| Description: |
circPRMT5 acts as an oncogenic circRNA in bladder cancer. Nanotube-delivered si-circPRMT5 silences circPRMT5, modulates the miR-30c/SNAIL1/E-cadherin axis, suppresses proliferation/migration/invasion and metastasis, and increases apoptosis in vitro and in multiple in vivo bladder cancer models. |
| Confidence score: |
0.5762 |