| Expression pattern: |
UP |
| Associated gene: |
RHPN2, CDK6, MMP9, Bax, Ki-67 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
Facilitates pancreatic cancer malignant progression by promoting cell proliferation, migration, invasion, angiogenesis, and tumor growth while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0000284 acts as a miR-1179 sponge to positively regulate RHPN2 expression through a ceRNA mechanism, thereby promoting pancreatic cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; EdU Staining; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0000284 might be a potential target for PC treatment. |
| Description: |
In pancreatic cancer, circ_0000284 is up-regulated in tumor tissues and cancer cell lines. It promotes proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000284 sponges miR-1179 to upregulate RHPN2, suggesting a circ_0000284/miR-1179/RHPN2 ceRNA axis and a potential therapeutic target. |
| Confidence score: |
0.8005 |