| Expression pattern: |
UP |
| Associated gene: |
SOX4, AGO2 |
| Associated microRNA: |
miR-30a-5p |
| Biological function: |
promotes immune evasion and resistance to anti-PD-1 immunotherapy in NSCLC |
| Molecular mechanism: |
Acts as an endogenous miR-30a-5p sponge to enhance SOX4 expression, leading to immune evasion and anti-PD-1 resistance. |
| Biological pathway or process: |
immune regulation (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; FISH / smFISH; circRIP; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Increased expression of hsa_circ_0020714 was significantly associated with a bad prognosis and resistance to anti-PD-1 immunotherapy in patients with NSCLC. |
| Description: |
hsa_circ_0020714 is upregulated in NSCLC tissues and is associated with poor prognosis and resistance to anti-PD-1 therapy. It promotes immune evasion by sponging miR-30a-5p, thereby increasing SOX4 expression, and enhances anti-PD-1 resistance in vivo. |
| Confidence score: |
0.7909 |