| Expression pattern: |
DN |
| Associated gene: |
PTEN, AGO2 |
| Associated microRNA: |
miR-23a-3p |
| Biological function: |
circFBXW7 overexpression inhibits glioma cell proliferation, migration, invasion, tumor growth and metastasis; low circFBXW7 expression is associated with shorter overall survival. |
| Molecular mechanism: |
circFBXW7 acts as a ceRNA that sponges miR-23a-3p, thereby increasing PTEN expression and suppressing glioma progression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circFBXW7 expression is closely related to tumor size and WHO grade, and patients with low circFBXW7 expression had shorter overall survival; circFBXW7 may offer a novel target for clinical therapy and diagnosis of glioma. |
| Description: |
circFBXW7 is downregulated in glioma tissues and cell lines and functions as a tumor-suppressive circRNA. Its overexpression inhibits glioma cell proliferation, migration, invasion, tumor growth and metastasis by sponging miR-23a-3p and increasing PTEN expression. Clinically, lower circFBXW7 expression is associated with larger tumor size, higher WHO grade and shorter overall survival. |
| Confidence score: |
0.7779 |