| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin, Vimentin |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0011946 promotes HCC cell migration and invasion and is associated with lymphatic metastasis; knockdown inhibits migration, invasion and EMT process. |
| Molecular mechanism: |
hsa_circ_0011946 induces the EMT process in HCC, with knockdown increasing E-cadherin and decreasing N-cadherin and Vimentin expression. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
high hsa_circ_0011946 expression was associated with lymphatic metastasis and may serve as a prospective therapeutic target for HCC |
| Description: |
This study found that hsa_circ_0011946 is up-regulated in HCC tissues and cell lines. Functional knockdown experiments showed that hsa_circ_0011946 promotes HCC cell migration and invasion, likely by inducing EMT-related changes involving E-cadherin, N-cadherin and Vimentin. Clinically, high hsa_circ_0011946 expression was associated with lymphatic metastasis, suggesting potential value as a therapeutic target. |
| Confidence score: |
0.5358 |