circRNA basic information
circBase ID: hsa_circ_0003028
Name: hsa_circ_FUT8
Synonym: circFUT8
Host Gene: FUT8
Genomic location(hg19): chr14:66028054-66028484:+
Genomic location(hg38): chr14:65561336-65561766:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: Bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BCa tissues; adjacent normal bladder tissues; tumor tissues
Cell lines:

T24; UM-UC-3
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: FMR1, YTHDC1, METTL14
Associated microRNA: -
Biological function: circFUT8 inhibits BCa cell growth, proliferation, migration, and tumor growth; restoration of circFUT8 acts as a tumor suppressor in BCa.
Molecular mechanism: METTL14 promotes m6A modification and expression of circFUT8; FMR1 directly binds circFUT8 and promotes its expression, forming a METTL14/FMR1/circFUT8 axis that suppresses BCa growth and migration.
Biological pathway or process:

m6A modification (other); proliferation (inhibits); migration (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Bioinformatics Analysis; Transfection; EdU Staining; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

circFUT8 may serve as a promising therapeutic target for early intervention in BCa.
Description:

circFUT8 is significantly downregulated in bladder cancer tissues and functions as a tumor-suppressive circRNA. METTL14 promotes circFUT8 m6A methylation and expression, while the m6A reader/RBP FMR1 directly binds circFUT8 and enhances its expression; activation of this METTL14/FMR1/circFUT8 axis inhibits BCa cell proliferation, migration, and tumor growth.
Confidence score:

0.7078
Other information
Title:

Bladder Cancer Growth is Inhibited by Upregulating CircFUT8 through the METTL14/FMR1 Signaling Pathway.

Journal: Cell biochemistry and biophysics
Published: 2025
PubMed ID: 40493341
Study type:

combined biological and clinical study
Data availability: TCGA database; data available from corresponding author upon reasonable request; supplementary material available at https://doi.org/10.1007/s12013-025-01794-3
Code availability: -