| Expression pattern: |
UP |
| Associated gene: |
FSTL1 |
| Associated microRNA: |
miR-134-5p |
| Biological function: |
Promotes PTC cell proliferation, migration, glycolytic metabolism and tumorigenesis in vivo. |
| Molecular mechanism: |
circ_0002111 acts as a miR-134-5p sponge to upregulate FSTL1 expression, thereby promoting malignant progression and glycolytic metabolism in PTC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circ_0002111 is significantly upregulated in PTC patient samples and may provide important information for the regulatory mechanism of circ_0002111 in PTC. |
| Description: |
circ_0002111 is upregulated in papillary thyroid carcinoma tissues and cells. It promotes PTC proliferation, migration, glycolytic metabolism and xenograft tumor growth by sponging miR-134-5p and increasing FSTL1 expression. |
| Confidence score: |
0.7597 |