circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1
Synonym: CDR1as
Host Gene: CDR1
Genomic location(hg19): chrX:139865340-139866824:.
Genomic location(hg38): chrX:140783175-140784659:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005081
MONDO name: preeclampsia
Disease details: Preeclampsia
Disease DO ID:
 10591
Disease MeSH ID:
 D011225
Disease NCIt ID:
 C85021
Disease ICD11 ID:
 229121159
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

placenta / placental samples / placental biopsies
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: miR-7 / miR-7-5p
Biological function: miRNA sponge activity (inhibits miR-7 action) in placenta; role in disease not evaluated
Molecular mechanism: Predicted/known miRNA sponge with multiple miR-7 seed matches; validated BSJ by RT-qPCR and Sanger sequencing in placental samples
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

-
Description:

CDR1as (CiRS-7) is present in human placental RNA datasets and was experimentally confirmed by RT-qPCR and Sanger sequencing of the back-splice junction. It is described as a miRNA sponge with many predicted miR-7(-5p) binding sites; disease-associated expression/roles (PE/FGR) were not reported for this circRNA.
Confidence score:

0.4773
Other information
Title:

The RNA landscape of the human placenta in health and disease.

Journal: Nature communications
Published: 2021
PubMed ID: 33976128
Study type:

combined biological and clinical study
Data availability: EGAD00001003457; EGAD00001003507; EGAD00001003508; EGAD00001006304; EGAD00001004860; https://www.obgyn.cam.ac.uk/placentome/; PXD000561; PXD010154
Code availability: https://github.com/sung/POPS-Placenta-Transcriptome-2020; https://github.com/sung/ShinyPlacentome