| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circPVT1 is up-regulated in NSCLC serum, associated with advanced p-TNM stage and poor differentiation, associated with chemotherapy resistance to cisplatin combined with gemcitabine, and high circPVT1 expression predicts lower survival. |
| Molecular mechanism: |
- |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High circPVT1 expression is associated with lower survival rate and poor prognosis in NSCLC; circPVT1 expression is associated with differentiation, p-TNM stage, and chemotherapy resistance after cisplatin combined with gemcitabine chemotherapy. |
| Description: |
This clinical study found that serum circPVT1 is up-regulated in NSCLC before chemotherapy and decreases after cisplatin plus gemcitabine treatment. Higher circPVT1 expression is associated with chemotherapy resistance, advanced clinical features, and poorer survival, suggesting its potential clinical value for prognosis and therapy-response assessment. |
| Confidence score: |
0.4758 |