| Expression pattern: |
UP |
| Associated gene: |
HNRNPU, EGFR |
| Associated microRNA: |
- |
| Biological function: |
Promotes gastric cancer cell proliferation, DNA synthesis, migration, and invasion; supports cell cycle progression; promotes gastric cancer progression. |
| Molecular mechanism: |
circSLC22A23 binds HNRNPU and activates HNRNPU expression, thereby promoting EGFR expression/transcription in gastric cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); EGFR (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSLC22A23 expression was positively correlated with vascular invasion and worse prognosis; circSLC22A23 may serve as a potential therapeutic target for gastric cancer. |
| Description: |
circSLC22A23 is up-regulated in gastric cancer tissues, plasma, and cell lines and high expression is associated with vascular invasion and worse prognosis. Functionally, circSLC22A23 promotes GC cell proliferation, migration, and invasion. Mechanistically, it binds HNRNPU and activates EGFR expression, supporting an oncogenic circSLC22A23-HNRNPU-EGFR regulatory mechanism. |
| Confidence score: |
0.8632 |