| Expression pattern: |
UP |
| Associated gene: |
Bcl-6 / B-cell CLL/lymphoma 6 |
| Associated microRNA: |
hsa-miR-139-3p |
| Biological function: |
hsa_circ_0031288 promotes cervical cancer HeLa cell proliferation, invasion, migration, and xenograft tumor growth; reducing hsa_circ_0031288 inhibits these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0031288 acts as a sponge for hsa-miR-139-3p, inhibits hsa-miR-139-3p expression, and relieves miR-139-3p-mediated inhibition of Bcl-6 within the hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
hsa_circ_0031288 may be a useful marker for early cervical cancer diagnosis and a potential intervention target for cervical cancer treatment. |
| Description: |
hsa_circ_0031288 is up-regulated in cervical cancer tissues and HeLa cells. It promotes cervical cancer cell proliferation, invasion, migration, and xenograft tumor growth, likely by sponging hsa-miR-139-3p and thereby relieving inhibition of Bcl-6. The study suggests hsa_circ_0031288 may serve as an early diagnostic marker and therapeutic intervention target in cervical cancer. |
| Confidence score: |
0.7032 |