circRNA basic information
circBase ID: hsa_circ_0002052
Name: -
Synonym: circ-0002052
Host Gene: -
Genomic location(hg19): chr9:118969734-118997916:+
Genomic location(hg38): chr9:116207455-116235637:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; non-cancer tissues; non-tumor controls
Cell lines:

U2OS; U2OS/MTX300; HOS; MG63; 143B; ZOS; ZOSM; hFOB 1.19; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: STX6, Wnt/beta-catenin, MYC, SOX4, CCND1
Associated microRNA: miR-382
Biological function: Promotes osteosarcoma progression by enhancing OS cell proliferation, migration, and invasion; high expression is associated with advanced stage, larger tumor size, metastasis, and lower survival rate.
Molecular mechanism: circ-0002052 acts as a miR-382 sponge, relieves miR-382-mediated suppression of STX6, and activates Wnt/beta-catenin signaling.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High circ-0002052 expression is associated with advanced stage, tumor size, metastasis, and low survival rate, suggesting circ-0002052 may be a prognostic biomarker and potential treatment target for osteosarcoma.
Description:

hsa_circ_0002052/circ-0002052 is up-regulated in osteosarcoma tissues and cells and is associated with advanced stage, tumor size, metastasis, and poor survival. Functionally, it promotes OS cell proliferation, migration, and invasion by sponging miR-382, increasing STX6 expression, and activating Wnt/beta-catenin signaling, suggesting prognostic and therapeutic relevance.
Confidence score:

0.8244
Other information
Title:

Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis.

Journal: Human cell
Published: 2020
PubMed ID: 32274658
Study type:

combined biological and clinical study
Data availability: GSE96964; GPL19978
Code availability: -