circRNA basic information
circBase ID: hsa_circ_0060927
Name: hsa_circ_CYP24A1
Synonym: -
Host Gene: CYP24A1
Genomic location(hg19): chr20:52773707-52788209:-
Genomic location(hg38): chr20:54157168-54171670:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007886
MONDO name: uterine corpus leiomyoma
Disease details: uterine leiomyomas
Disease DO ID:
 13223
Disease MeSH ID:
 -
Disease NCIt ID:
 C3434
Disease ICD11 ID:
 -
Disease OMIM ID:
 150699
Species: Human
Species details: Homo sapiens
Tissue specimen:

leiomyoma samples; adjacent tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DNMT1, SOCS3
Associated microRNA: miR‐29b‐1‐5p, miR‐224‐3p, miR‐522‐3p, miR‐661, miR‐1264
Biological function: May contribute to uterine leiomyoma pathology (proposed via miRNA sponging leading to increased DNMT1 transcripts and SOCS3 hypermethylation).
Molecular mechanism: Putative miRNA sponging (ceRNA-like) mechanism involving miR1264 and DNMT1/SOCS3 methylation regulation (hypothesized).
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

This study reports ectopic expression of hsa_circ_0060927 (from CYP24A1) in a subset of uterine leiomyoma tissues while absent in adjacent normal tissues, and finds no significant association with MED12 mutation status. A miRNA-sponging mechanism (e.g., via miR-1264 affecting DNMT1/SOCS3 methylation) is discussed as a hypothesis but not experimentally validated here.
Confidence score:

0.429
Other information
Title:

Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 31746073
Study type:

clinical study
Data availability: -
Code availability: -