| Expression pattern: |
DN |
| Associated gene: |
HOXD3 |
| Associated microRNA: |
miR-345-5p |
| Biological function: |
circ_0027345 overexpression promoted HCC cell viability, cell cycle progression, migration and invasion, and inhibited apoptosis and autophagy (counteracting matrine effects). |
| Molecular mechanism: |
ceRNA mechanism: circ_0027345 sponges miR-345-5p to augment HOXD3 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); autophagy (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
In HCC cells, matrine decreases circ_0027345 expression. circ_0027345 functions as a ceRNA by sponging miR-345-5p, thereby increasing HOXD3 and promoting proliferation, migration/invasion while suppressing apoptosis and autophagy; circ_0027345 overexpression reverses matrine’s anti-tumor effects. |
| Confidence score: |
0.5309 |