circRNA basic information
circBase ID: hsa_circ_0003528
Name: hsa_circ_SEC24A
Synonym: circSEC24A
Host Gene: SEC24A
Genomic location(hg19): chr5:134032815-134044578:+
Genomic location(hg38): chr5:134697125-134708888:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; adjacent non-tumor tissues; TNBC tissues
Cell lines:

MCF-10 A; MDA-MB-231; HCC1937; BT549; MDA-MB-468
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-215
Biological function: hsa_circ_0003528 promotes aggressive cellular behaviors in TNBC, including proliferation, migration, and invasion; its knockdown suppresses these behaviors.
Molecular mechanism: hsa_circ_0003528 may sponge or bind miR-215 and facilitate TNBC tumorigenesis by regulating miR-215 expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay
Clinical significance:

High hsa_circ_0003528 expression was associated with tumor size, clinical stage, grade, lymph node metastasis, shorter overall survival, and may serve as a prognostic predictor for TNBC patients.
Description:

hsa_circ_0003528/circSEC24A is upregulated in breast cancer, particularly TNBC, and high expression is associated with adverse clinicopathological features and poor overall survival. Functionally, hsa_circ_0003528 promotes TNBC cell proliferation, migration, and invasion, at least partly by binding/regulating miR-215. The study suggests hsa_circ_0003528 as a prognostic biomarker and potential therapeutic target for TNBC.
Confidence score:

0.7513
Other information
Title:

CircRNA hsa_circ_0003528/miR-215 is considered a potential target for predictive prognosis and therapy for triple-negative breast cancer.

Journal: Molecular biology reports
Published: 2024
PubMed ID: 39126511
Study type:

combined biological and clinical study
Data availability: GSE101123
Code availability: -