| Expression pattern: |
DN |
| Associated gene: |
ARID1A, AGO2 |
| Associated microRNA: |
miR-223-3p |
| Biological function: |
hsa_circ_0002669 suppresses GC cell proliferation, invasion, migration, tumor growth, and lung metastasis. |
| Molecular mechanism: |
hsa_circ_0002669 acts as a competing endogenous RNA sponge for miR-223-3p, thereby upregulating ARID1A; H. pylori infection decreases hsa_circ_0002669 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
potential novel diagnostic marker and therapeutic target for GC |
| Description: |
hsa_circ_0002669 is down-regulated in gastric cancer tissues and GC cell lines, and H. pylori infection further decreases its expression. It functions as a tumor-suppressive circRNA that inhibits GC cell proliferation, migration, invasion, tumor growth, and lung metastasis. Mechanistically, cytoplasmic hsa_circ_0002669 sponges miR-223-3p to increase ARID1A protein expression, supporting its potential as a diagnostic marker and therapeutic target. |
| Confidence score: |
0.8366 |