circRNA basic information
circBase ID: hsa_circ_0004619
Name: hsa_circ_FAF1
Synonym: hsa_circ_100219
Host Gene: FAF1
Genomic location(hg19): chr1:51121113-51210447:-
Genomic location(hg38): chr1:50655441-50744775:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer lesions; adjacent normal-appearing tissues; breast cancer tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-135b-3p, hsa-miR-298, hsa-miR-485-3p, hsa-miR-182-5p, hsa-miR-593-5p
Biological function: Proposed diagnostic biomarker; may be linked to apoptosis via FAF1 context.
Molecular mechanism: Predicted miRNA sequestration via MREs; matched with miR-135b.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Highest diagnostic accuracy among the six circRNAs (AUC = 0.78, 95% CI: 0.69-0.88); contributes to combined AUC = 0.82 with hsa_circ_006054 and hsa_circ_406697.
Description:

hsa_circ_100219 (circBase: hsa_circ_0004619) is down-regulated in breast cancer tissues and showed the best diagnostic performance (AUC 0.78) among the tested circRNAs; it is predicted to bind several miRNAs (including miR-135b-3p, miR-298, miR-485-3p).
Confidence score:

0.5963
Other information
Title:

Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.

Journal: Oncotarget
Published: 2017
PubMed ID: 28484086
Study type:

combined biological and clinical study
Data availability: -
Code availability: -