circRNA basic information
circBase ID: hsa_circ_0002618
Name: hsa_circ_MGA
Synonym: -
Host Gene: MGA
Genomic location(hg19): chr10:22171210-22209892:-
Genomic location(hg38): chr10:21882281-21920963:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HUO3N1; CAL78; hFOB1.19; NOS1; U2OS; HOS
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: 73 mRNAs, MGA
Associated microRNA: hsa-miR-154-3p, hsa-miR-487a-3p, hsa-miR-216a-3p
Biological function: Potentially participates in osteosarcoma metastasis and is associated with cancer-related pathways in the predicted ceRNA network.
Molecular mechanism: circRNA-based competing endogenous RNA network involving miRNAs and mRNAs
Biological pathway or process:

ceRNA regulation (other); metastasis (other); mTOR signaling pathway (other); stemness (other); drug resistance (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0002618 was identified as a metastasis-related circRNA in osteosarcoma cell lines and included in a predicted ceRNA network. Bioinformatic analyses associated it with cancer-related pathways, suggesting a possible role in OS metastasis.
Confidence score:

0.1768
Other information
Title:

Comprehensive characterization of circular RNAs in osteosarcoma cell lines.

Journal: Cellular signalling
Published: 2020
PubMed ID: 32199934
Study type:

bioinformatics study
Data availability: SRP157750; TARGET database; Supplementary data: https://doi.org/10.1016/j.cellsig.2020.109603
Code availability: -