| Expression pattern: |
DN |
| Associated gene: |
PEBP1 |
| Associated microRNA: |
miR-3200-5p |
| Biological function: |
CircMTO1 suppresses GC progression by inhibiting cell proliferation, colony formation, migration, invasion and EMT process. |
| Molecular mechanism: |
CircMTO1 acts as a miR-3200-5p sponge and regulates PEBP1 expression through the miR-3200-5p/PEBP1 axis. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circMTO1 may become a new promising therapeutic target for GC patients. |
| Description: |
circMTO1 is down-regulated in gastric carcinoma tissues and cell lines. It functions as a tumor-suppressive circRNA by sponging miR-3200-5p and regulating PEBP1, thereby inhibiting GC cell proliferation, migration, invasion and EMT. The study suggests circMTO1 as a potential therapeutic target for GC. |
| Confidence score: |
0.7283 |