| Expression pattern: |
UP |
| Associated gene: |
STAT3, HIF-1a |
| Associated microRNA: |
miR-516b-5p |
| Biological function: |
circAKT3 promotes cisplatin resistance, HIF-1a-dependent glycolysis and tumor growth in lung cancer; knockdown of circAKT3 increases cisplatin sensitivity, represses glycolysis and suppresses xenograft tumor growth. |
| Molecular mechanism: |
circAKT3 acts through the miR-516b-5p/STAT3 axis to regulate HIF-1a-dependent glycolysis and cisplatin sensitivity. |
| Biological pathway or process: |
glycolysis (promotes); chemoresistance (promotes); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
These findings provided new insights and ideas for clinical prediction and treatment of lung cancer. |
| Description: |
circAKT3 is up-regulated in lung cancer tissues and cell lines. It promotes cisplatin resistance and glycolysis, at least partly through regulation of the miR-516b-5p/STAT3 axis and HIF-1a-dependent glycolysis; circAKT3 knockdown increases cisplatin sensitivity and suppresses tumor growth in vivo. |
| Confidence score: |
0.6479 |