| Expression pattern: |
UP |
| Associated gene: |
PKM2 |
| Associated microRNA: |
miR-7-5p |
| Biological function: |
Promotes glycolysis, cell proliferation, and oxaliplatin resistance, and inhibits apoptosis in L-OHP-resistant CRC cells; circAGFG1 knockdown enhances L-OHP sensitivity in vitro and in vivo. |
| Molecular mechanism: |
circAGFG1 acts through a ceRNA-like mechanism by binding miR-7-5p and regulating PKM2 expression, thereby modulating glycolysis and oxaliplatin sensitivity. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circAGFG1 expression predicted a poor prognosis of CRC and circAGFG1 may be a therapeutic target for L-OHP-resistant CRC. |
| Description: |
circAGFG1 is up-regulated in oxaliplatin-resistant colorectal cancer tissues and cells, and high expression is associated with poor prognosis. Functionally, circAGFG1 promotes glycolysis, proliferation, and L-OHP resistance while suppressing apoptosis. Mechanistically, circAGFG1 regulates PKM2 expression through miR-7-5p, forming a circAGFG1/miR-7-5p/PKM2 axis that affects oxaliplatin sensitivity. |
| Confidence score: |
0.8198 |