| Expression pattern: |
UP |
| Associated gene: |
KLF10 |
| Associated microRNA: |
miR-197-3p |
| Biological function: |
promotes osteosarcoma cell proliferative ability and invasiveness; promotes osteosarcoma progression |
| Molecular mechanism: |
circ-0003998 binds to miR-197-3p and up-regulates KLF10 expression, thereby promoting osteosarcoma cell growth and invasion |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circ-0003998 predicts poor clinical prognosis of patients with osteosarcoma |
| Description: |
circ-0003998 is up-regulated in osteosarcoma tissues and cell lines, and high expression is associated with reduced overall survival. Functionally, circ-0003998 promotes osteosarcoma cell proliferation and invasion. Mechanistically, it binds miR-197-3p and up-regulates KLF10 expression, thereby accelerating osteosarcoma progression. |
| Confidence score: |
0.7113 |