circRNA basic information
circBase ID: hsa_circ_0000282
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:28250417-28255132:+
Genomic location(hg38): chr11:28228870-28233585:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues / adjacent normal tissue specimens
Cell lines:

MG-63; U2-OS; 143B; SOSP-9607; hFOB1.19; HEK-293
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: XIAP, Ago2
Associated microRNA: miR-192
Biological function: Promotes osteosarcoma cell proliferation and suppresses apoptosis.
Molecular mechanism: Acts as a ceRNA/miRNA sponge to adsorb miR-192, indirectly up-regulating XIAP.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; BrdU; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

High circ_0000282 expression was associated with higher Enneking stage and lower tumor differentiation degree; it is probably associated with unfavorable prognosis.
Description:

hsa_circ_0000282 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation while inhibiting apoptosis. Mechanistically, it sponges miR-192 to relieve repression of XIAP, forming a circ_0000282/miR-192/XIAP ceRNA axis.
Confidence score:

0.7032
Other information
Title:

Circular RNA hsa_circ_0000282 contributes to osteosarcoma cell proliferation by regulating miR-192/XIAP axis.

Journal: BMC cancer
Published: 2020
PubMed ID: 33097010
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -