| Expression pattern: |
UP |
| Associated gene: |
PFKFB3 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
Promotes breast cancer cell proliferation, metastasis, glycolysis and tumorigenesis; circ_0102273 knockdown inhibits proliferation, migration, invasion, glycolysis and in vivo tumor growth. |
| Molecular mechanism: |
circ_0102273 acts as a sponge for miR-1236-3p to positively regulate PFKFB3 expression, thereby promoting breast cancer proliferation, metastasis and glycolysis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes); apoptosis (inhibits); angiogenesis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; EdU Staining; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0102273 might be a potential target for BC treatment; targeted inhibition of circ_0102273 might be an effective pathway to restrain BC progression. |
| Description: |
circ_0102273 is up-regulated in breast cancer tumor tissues and cell lines. It promotes breast cancer proliferation, migration, invasion, glycolysis and in vivo tumorigenesis by sponging miR-1236-3p and positively regulating PFKFB3. The study proposes the circ_0102273/miR-1236-3p/PFKFB3 axis as a potential molecular target for breast cancer treatment. |
| Confidence score: |
0.8298 |