| Expression pattern: |
UP |
| Associated gene: |
ARHGAP1 |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
circ_RPPH1 promotes breast cancer cell proliferation, migration, invasion, EMT, and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circ_RPPH1 acts as a miR-542-3p sponge to upregulate ARHGAP1 expression, thereby contributing to breast cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ_RPPH1 was suggested as a novel target for BC treatment. |
| Description: |
circ_RPPH1 is up-regulated in breast cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-542-3p and thereby increasing ARHGAP1 expression, which promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while suppressing apoptosis. |
| Confidence score: |
0.7595 |