| Expression pattern: |
UP |
| Associated gene: |
SOX2 |
| Associated microRNA: |
miR-557 |
| Biological function: |
promotes HCC cell growth, proliferation, migration, invasion, EMT process, and lung metastasis |
| Molecular mechanism: |
circ_0040705 functions as a competitive endogenous RNA sponge for miR-557, down-modulating miR-557 and indirectly up-regulating SOX2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
circ_0040705 is up-regulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, EMT-related changes, and lung metastasis by sponging miR-557 and indirectly increasing SOX2 expression. |
| Confidence score: |
0.6835 |