circRNA basic information
circBase ID: hsa_circ_0051428
Name: -
Synonym: circ_0051428 / hsa_circ_102566
Host Gene: -
Genomic location(hg19): chr19:45525310-45528995:+
Genomic location(hg38): chr19:45022052-45025737:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; corresponding normal tissues
Cell lines:

HeLa; CaSki; SiHa; C33A; HcerEpic
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MMP2, Ago2
Associated microRNA: miR-885-3p
Biological function: promotes proliferation; promotes invasion; promotes tumor growth
Molecular mechanism: ceRNA mechanism: circ_0051428 sponges miR-885-3p to regulate MMP2 expression
Biological pathway or process:

proliferation (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model
Clinical significance:

-
Description:

circ_0051428 is up-regulated in cervical cancer tissues and cell lines and promotes malignant behaviors (proliferation, invasion) and xenograft tumor growth. Mechanistically, it acts as a miR-885-3p sponge to de-repress the miR-885-3p target MMP2, forming a circ_0051428/miR-885-3p/MMP2 axis.
Confidence score:

0.7631
Other information
Title:

Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer.

Journal: Open medicine (Warsaw, Poland)
Published: 2024
PubMed ID: 38584845
Study type:

combined biological and clinical study
Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -