| Expression pattern: |
UP |
| Associated gene: |
CCT2, DKC1, NAT10, HSPH1, HSPD1 |
| Associated microRNA: |
hsa-miR-664b-3p, hsa-miR-139-5p, hsa-miR-6509-5p, hsa-miR-323a-3p, hsa-miR-370-3p, hsa-miR-181a-5p, hsa-miR-181b-5p |
| Biological function: |
Predicted oncogenic role in CRC; participates in regulation of telomere maintenance, posttranslational protein folding, apoptotic process and metabolic processes, and may promote tumor survival through anti-apoptotic effects. |
| Molecular mechanism: |
Predicted ceRNA mechanism in a circRNA/miRNA/mRNA regulatory network; hsa_circ_0030632 was predicted to regulate CRC-associated genes including CCT2, DKC1, NAT10, HSPH1, and HSPD1. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May facilitate the finding of promising targets and biomarkers in CRC. |
| Description: |
hsa_circ_0030632 is an up-regulated circRNA in CRC tissues and cell lines validated by qPCR. The study predicts that it acts through a circRNA/miRNA/mRNA regulatory network and may have an oncogenic role by regulating telomere maintenance, posttranslational protein folding, anti-apoptotic processes and metabolic programs. |
| Confidence score: |
0.585 |